The Covid-19 pandemic will “look minor” compared with what humanity faces from the growing number of superbugs resistant to current drugs, Prof Dame Sally Davies, England’s former chief medical officer, has warned.

Davies, who is now the UK’s special envoy on antimicrobial resistance (AMR), lost her goddaughter two years ago to an infection that could not be treated.

She paints a bleak picture of what could happen if the world fails to tackle the problem within the next decade, warning that the issue is “more acute” than climate change. Drug-resistant infections already kill at least 1.2 million people a year.

“It looks like a lot of people with untreatable infections, and we would have to move to isolating people who were untreatable in order not to infect their families and communities. So it’s a really disastrous picture. It would make some of Covid look minor,” said Davies, who is also the first female master of Trinity College, Cambridge.

AMR means that some infections caused by bacteria, viruses, fungi and parasites can no longer be treated with available medicines. Exposure to drugs allows the bugs to evolve the ability to resist them, and overuse of drugs such as antibiotics accelerates that process.

Widespread resistance would make much of modern medicine too risky, affecting treatments including caesarean sections, cancer interventions and organ transplantation.

“If we haven’t made good strides in the next 10 years, then I’m really scared,” Davies said.

Without the development of new treatments “it’ll grind on for decades and it won’t burn out. We know that with viruses, they burn out, you generally develop herd immunity, but this isn’t like that.”

Last week the UK government announced a national action plan on AMR, with commitments to reduce its use of antimicrobials in both humans and animals, strengthen surveillance of drug resistant infections, and incentivise industry to develop new drugs and vaccines.

Launching the plan, Maria Caulfield, the health minister, said: “In a world recovering from the profound impact of the Covid-19 pandemic, international collaboration and preparedness for global health challenges have taken on an unprecedented level of importance.”

Davies has spent more than a decade warning about the problem, but said it truly hit home when her “beautiful” goddaughter, Emily Hoyle, died of a drug-resistant infection aged 38.

Hoyle had cystic fibrosis and had undergone two lung transplants before she was infected by Mycobacteroides abscessus, which was resistant to treatment.

The team treating her “tried everything”, Davies said. “But I would think for me, looking back from the year before she died, I thought it was likely this would kill her.

“And she knew about six months before she died that this was not going to be treatable and that she would probably die of it.

“She had a very beautiful death – she was very dignified, laughing, joking, making light of it to husband, family, all of us. She was very special.

“But she gave me permission to use her story as my goddaughter because, well, it got personal for me, the Christmas before last.”

Hoyle’s death has reinforced her determination to turn the tide, Davies said, describing it as a question of intergenerational fairness.

“My generation and older have used the antibiotics [and] we’re not replenishing them. We’re not making sure that our food is produced with as low usage as possible. And I owe it to my children and – if I have them – grandchildren and the next generations to do my best.”

There are also issues of fairness in the present day, she said. One death in five caused by AMR is in a child aged under five, usually in sub-Saharan Africa, where Davies said the problem is “particularly prevalent and disastrous”.

Many of the countries are also being hit hard by the climate crisis and Davies said the two problems were interlinked.

“If we don’t control and mitigate AMR, then it will kill more people before climate change does,” she said.

“Climate will play out in many ways, but think about flood water, think about sewage, think about displacement, think about storms and what they spread and the lack of clean water if you’ve got drought; infections do go up.”

There are global efforts to reduce inappropriate use of drugs such as antibiotics in medicine, although the Covid-19 pandemic stalled progress on many of those initiatives. Few new antibiotics have been created in recent years and the issue is “made more complicated” because it involves sectors such as farming as well as human health.

More than two-thirds of antibiotics go into farm animals, Davies said, usually to promote growth or prevent infections in overcrowded, unsanitary conditions rather than treat specific infections.

Some Asian fish farms were “tipping antibiotics in with the fish food”, partly because it is cheaper, she said, but also because of a lack of research into which infections occur in local breeds of fish such as tilapia, and which vaccines might be needed.

“If you don’t have appropriate, careful use,” she said, “you’re risking it really getting out of control.”

Animals, including humans, excrete up to 80% of the antibiotics they take in, she points out, “contaminating the environment”. Factories producing antibiotics may not control their effluent, allowing “dramatic amounts” to enter water systems.

Despite her warnings, Davies insisted she is a “glass half-full” person, brimming with enthusiasm as she discusses projects that find a different approach. A major US poultry supplier has stopped using antibiotics, “so you can do it”, she said.

Breakthroughs such as genomics and artificial intelligence are “reinvigorating” the science of new antibiotics. She is also hopeful that programmes to incentivise pharmaceutical companies to create new antibiotics will bear fruit.

Ideally, such medicines should be held in reserve as a last resort if existing drugs fail to work, so bugs do not develop resistance to them. However, this makes it hard for companies to guarantee a return on investment in research and development.

Various countries are exploring alternative means of funding, such as a subscription model by NHS England, paying a fixed annual fee for access to antimicrobials, regardless of volume used.

Davies is part of the UN Global Leaders Group on AMR. In September, the UN will hold a high-level meeting on the issue and the group is pushing for targets by 2030, including reducing global human deaths from AMR by 10%, cutting antimicrobial use in agriculture by at least 30%, and ending the use of “medically important antimicrobials for human medicine” in farming where they are not needed to treat disease.

While “honoured” to be part of the group, she said more formal structures were needed. “We need inter-country governance of some form, a bit like a COP for climate change,” Davies said.

Particularly important would be the establishment of an independent scientific panel similar to the IPCC, “otherwise, it’s academics saying, ‘oh, we need this target’. And however correct that is, if you haven’t taken the low- and middle-income countries on the journey, there’s no reason why they would accept those – or should accept them.”

Twenty-seven new bathing sites will be designated in England ahead of this summer’s swimming season, the government has announced.

Giving waterways bathing status means the Environment Agency has to test them for pollution during the summer months, putting pressure on water companies to stop dumping sewage in them.

Twelve rivers are among the new sites. There are three river areas in England designated for swimming, far fewer than in many other European countries. In France, for example, there are more than 570 river bathing sites.

Bathing status is no guarantee the waters are safe to swim in, however. Last year, testing by the Environment Agency found that England’s three river swimming areas all had “poor” status due to pollution. This means people should not swim in them and risk getting sick if they do. Sewage spills and agricultural runoff mean swimming sites can carry E coli and intestinal enterococci, which could make swimmers ill.

The water campaigner and former Undertones singer Feargal Sharkey told the Guardian: “Every single stretch of river in England currently tested carries a ‘do not swim’ advisory. This lot will simply join that ignoble, floundering list of failure.

“It’s clearly not a strategy to deal with the decaying state of our rivers, it’s simply panic from a decaying government, it’s making excuses all before exiting stage left in the run-up to a general election.”

Water companies were criticised for record sewage discharges into England’s waterways last year. Recent data showed raw sewage was discharged into rivers and seas for more than 3.6 million hours, more than double that in the previous 12 months.

Bathing sites are only tested in the summer months but the government has promised a consultation later this year on proposals that would include extending monitoring outside the bathing season, as some people use the rivers recreationally all year.

The water minister, Robbie Moore, said: “The value our bathing waters bring to local communities is incredibly valuable – providing social, physical and positive health and wellbeing benefits to people around the country – and I am pleased to have approved a further 27 new bathing water sites for this year.

“These popular swimming spots will now undergo regular monitoring to ensure bathers have up-to-date information on the quality of the water and enable action to be taken if minimum standards aren’t being met.”

The chair of the Environment Agency, Alan Lovell, said: “The importance of England’s bathing waters for residents and visitors alike cannot be overstated, which is why the Environment Agency provides rigorous testing to ensure that bathers can make informed decisions before swimming in one of our 451 sites.

“Overall bathing water quality has improved massively over the last decade due to targeted and robust regulation from the Environment Agency, and the good work carried out by partners and local groups. Last year, 96% of sites met minimum standards, up from just 76% in 2010 – and despite stricter standards being introduced in 2015. We know that improvements can take time and investment from the water industry, farmers and local communities, but where the investment is made, standards can improve.”

The new bathing sites

• River Wharfe at Wetherby Riverside, High St, Wetherby, West Yorkshire

The world’s big banks have handed nearly $7tn (£5.6tn) in funding to the fossil fuel industry since the Paris agreement to limit carbon emissions, according to research.

In 2016, after talks in Paris, 196 countries signed an agreement to limit global heating as a result of carbon emissions to at most 2C above preindustrial levels, with an ideal limit of 1.5C to prevent the worst impacts of a drastically changed climate.

Many countries have since promised to reduce carbon emissions, but the latest research shows private interests continued to funnel money to oil, gas and coal companies, which have used it to expand their operations.

Eight in 10 of the world’s most eminent climate scientists now foresee at least 2.5C of global heating, according to the results of a Guardian survey published last week – an outcome expected to lead to devastating consequences for civilisation.

Researchers for the banking on climate chaos report, now in its 15th edition, analysed the world’s top 60 banks’ underwriting and lending to more than 4,200 fossil fuel firms and companies causing the degradation of the Amazon and Arctic.

Those banks, they found, gave $6.9tn in financing to oil, coal and gas companies, nearly half of which – $3.3tn – went towards fossil fuel expansion. Even in 2023, two years after many large banks vowed to work towards lowering emissions as part of the Net Zero Banking Alliance, bank finance for fossil fuel companies was $705bn, with $347bn going towards expansion, the report says.

US banks were the biggest financiers of the fossil fuel industry, contributing 30% of the total $705bn provided in 2023, the report found. JP Morgan Chase gave the most of any bank in the world, providing $40.8bn to fossil fuel companies in 2023, while Bank of America came in third. The world’s second biggest financier of fossil fuels was the Japanese bank Mizuho, which provided $37.1bn.

London-based Barclays was Europe’s biggest fossil fuel financier, with $24.2bn, followed by Spain’s Santander at $14.5bn and Germany’s Deutsche Bank with $13.4bn. Overall, European banks stumped up just over a quarter of the total fossil fuel financing in 2023, according to the report.

Tom BK Goldtooth, the executive director of the Indigenous Environmental Network, which co-authored the study, said: “Financiers and investors of fossil fuels continue to light the flame of the climate crisis. Paired with generations of colonialism, the fossil fuel industry and banking institutions’ investment in false solutions create unlivable conditions for all living relatives and humanity on Mother Earth.

“As Indigenous peoples, we remain on the frontlines of the climate catastrophe, and the fossil fuel industry targets our lands and territories as sacrifice zones to continue their extraction. Capitalism and its extraction-based economy will only perpetuate more harm and destruction against our Mother Earth and it must come to an end.”

Critics of the report said its methodology, which relied on investigating deals reported by financial market data companies such as Bloomberg and Refinitiv, meant researchers did not have a detailed view of what was being financed, and by whom.

Specifically, syndicated loans, bond issues and underwriting arrangements often involved several banks with varying levels of exposure. And financing to fossil fuel companies to fund transition technology projects could not be distinguished from financing for new oil wells, they said.

Spokespeople for Barclays, Bank of America, JP Morgan Chase, Deutsche Bank and Santander all emphasised that their organisations were supporting energy sector clients’ transitions toward more sustainable business models. Mizuho declined a request for comment.

In a country where so much of society is still bisected along class lines, many have a very particular image of a clever person – and it’s roughly Stephen Fry. A grand-seeming Oxbridge-educated man with a posh accent and an interest in art and opera, who can recite passages of classic literature. Rob Rinder, the criminal barrister, broadcaster and host of Judge Rinder, fits well into this mould and loves all things “high culture” and intellectual pursuits. He is, as his co-host Rylan Clark says, “one of the cleverest blokes I know”. Meanwhile, Rinder says Clark “doesn’t know his arts from his elbow”. However, over the course of the three episodes of Rob and Rylan’s Grand Tour, Clark emerges as the brilliant mind, with levels of intelligence, wit and profundity that may have been overlooked because there remains a perception of what a clever person is like.

The pair position themselves as an odd couple from different sides of the tracks, being good mates, both going through “painful divorces” who, despite their divergent interests, have decided to embark on a journey that represents a fresh start. The series follows them through the “hedonism” of Venice, the Renaissance feast that is Florence and the baroque glory of Rome, replicating a journey made by Lord Byron, 200 years after his death at just 36. But as the series reminds us, this was not just a journey that Byron made: many of the “poshos” of the era would journey to Italy as a rite of passage, a form of cultural education to establish themselves as erudite individuals who understood art, history and the ways of the world.

We first see Rinder in Venice aboard a gondola, wanting to take in the historical traditions of the city. Clark is in a glitzy speedboat and is a little intimidated by all the art and opera ahead. But while Rinder is moved and fascinated by the galleries, concerts and archaeology of this and the other two cities, his response comes across as a little more shallow than Clark’s reflections. When discussing Caravaggio, castratos or the Colosseum, Rinder always seems to give the prototypical clever-person answer, while Clark connects to his surroundings on a molecular level, seeing in ancient ruins existential questions that connect to his own mortality and desire to achieve greatness.

Clark also brings a gorgeous vulnerability to the screen. Not only is he dealing with heartbreak, but also with the lingering insecurity of having been an object of ridicule in his early career. It’s a truly remarkable journey that he has been on, having first come to public attention as the runner-up on Signed By Katie Price before being labelled a “joke act” on The X Factor and finally hitting his stride as a presenter on This Morning, Big Brother’s Bit on the Side and Ready Steady Cook. But even if he is best known for being a larger-than-life camp icon who pokes fun at himself, it has become clear over the years – and is further illuminated by this programme – that Clark is an extremely smart and talented man who should not be underestimated.

The relationship between Rinder and Clark proves surprisingly sweet and tender, too. Although they often fall back into the clever one/silly one shtick, they seem to hold each other in equally high regard. Clark has little ego around the gaps in his knowledge and soaks up what Rinder tells him about the historical significance of the places that they visit. Rinder also gazes at him adoringly when Clark interprets what the Botticellis hanging in the Uffizi or the Venetian mask worn during the carnival symbolise to him.

While Rinder and Clark seem quite transformed by their journey and time together, ending the trip with their hearts a little less broken and open to the possibility of finding love again (albeit with an iron-clad prenup), what’s most interesting about the programme is how it challenges our perception of Clark. For centuries, the Grand Tour was undertaken by those who more closely resembled Rinder, people with the right sort of class and education, unlike Clark, who was a “ginger kid from a council flat in Stepney Green”. But it is lovely to behold where that kid has ended up, see his formidable mind absorb the glories of the journey Bryon once embarked on and watch his confidence bloom in the Italian sunshine.

Three people were killed and at least 12 were wounded Saturday night in a shooting at party in south Alabama.

Andre Reid with the Baldwin county sheriff’s office’s investigation division told WALA-TV that about 1,000 people were attending a May Day party near the community of Stockton when an altercation started and gunfire erupted. Reid said most of the victims were “younger people”.

There was not immediate word on whether arrests had been made. The Associated Press left a message with the sheriff’s office Sunday.

Stockton has a population of about 400 people. It is roughly 30 miles (48.3km) north-east of Mobile, Alabama.

Reid said no law enforcement officers were involved in the shooting, which was among more than 150 mass shootings reported in the US so far this year, according to the Gun Violence Archive.

The nonpartisan archive defines a mass shooting as one in which four or more victims are killed or wounded. Perennially high numbers of mass shootings in the US have prompted some to call for meaningful gun control, though Congress for the most part has not delivered it.

The mass shooting in Alabama was only one instance of high-profile gun violence seen in the US over the weekend, which culminated in Mother’s Day on Sunday.

Three Atlanta police officers were hospitalized with gunshot wounds after a confrontation that left a suspect dead Saturday evening, authorities said.

And in Euclid, Ohio, a police officer was shot and killed after being “ambushed” while answering a disturbance call, and a suspect was being sought, authorities said Sunday.

The Associated Press contributed reporting

Vladimir Putin has removed his longtime ally Sergei Shoigu as defence minister in the most significant reshuffle to the military command since Russian troops invaded Ukraine more than two years ago.

In a surprise announcement, the Kremlin said Andrei Belousov, a former deputy prime minister who specialises in economics, will replace Shoigu.

Putin, who was sworn into his fifth term as Russia’s leader earlier this week, proposed that Shoigu take the position as head of Russia’s powerful security council. It is currently led by Nikolai Patrushev, a hawkish former spy and one of Putin’s closest advisers.

Shoigu, Russia’s longest-serving minister, assumed leadership of the defence ministry in 2012 after his tenure as the emergency services minister. He has been leading Russia’s military through its full-scale invasion of Ukraine, which began in 2022.

As defence minister Shoigu was tasked with modernising Russia’s military and was believed to have direct access to Putin, going on regular hunting and fishing trips with him in Siberia.

Shoigu’s popularity in Russia grew after the illegal annexation of Crimea in 2014, which he was credited with orchestrating.

But he has come under intense criticism for Russia’s military setbacks after the February 2022 invasion, as well as for his inability to root out the widespread corruption that continues to plague the army. Most dramatically, Shoigu was forced to fend off an armed uprising last summer by mercenary leader Yevgeny Prigozhin, who had called for his arrest.

Shoigu’s position appeared to have weakened last month when the security services arrested his long-term confidant Timur Ivanov, a deputy defence minister, and charged him with large-scale corruption.

On paper, Sunday’s reorganisation places Shoigu in a position formally considered higher ranking than his role in the defence ministry in what some observers believe is a move by Putin that allows his old ally to save face.

Kremlin spokesperson Dmitry Peskov said that Putin decided to appoint Belousov, a veteran economist, to lead the defence ministry after Russia’s war spending had vastly increased.

“It’s very important to put the security economy in line with the economy of the country so that it meets the dynamics of the current moment,” Peskov said.

Peskov added that the Russian president had decided a civilian should head the defence ministry to ensure the department was “open to innovations and advanced ideas”.

Russia has presided over a massive ramping up of industrial military production over the last two years, with total defence spending rising to an estimated 7.5% of its GDP.

A former defence official who has worked with Shoigu, speaking on conditions of anonymity, said: “The Kremlin wants the ministry to be led by an economist who knows how to streamline its operations.

“The defence ministry is supposed to be efficient and well run, while the actual decisions on the battlefield are left to the military.”

Valery Gerasimov, the veteran chief of Russia’s general staff and someone with a more hands-on role when it comes to the fighting, will remain in post, the Kremlin said.

It remains unclear what position will be taken by Patrushev, who has led the security council since 2008 and is believed to have helped mastermind the invasion of Ukraine.

Peskov told Russian state media late on Sunday that Patrushev’s new role will be announced in the “next few days”.

Earlier this week it was announced that his son Dmitry Patrushev, formerly agriculture minister, will be promoted to deputy prime minister.

The television cut-aways to the ­enclosure housing the Arsenal ­supporters perfectly captured the anxiety. It was not supposed to be like this, not against this ­Manchester United. But the lesser spotted a­cceptable version of Erik ten Hag’s team was on show, fighting for the badge, and Arsenal were made to suffer.

Leandro Trossard scored their goal midway through the first half after a United defensive malfunction – of course it was – but the advantage was slender and everyone knew, most of all Mikel Arteta, that it could take only one moment to rub out.

With five minutes to go, there was thunder and lightning. Very, very frightening. Arsenal had not exactly made a habit of winning here in recent years, doing so only once in their previous 16 Premier League visits. They desperately needed the points, to answer Manchester City’s victory at Fulham on Saturday, to jump back above them at the top of the table, to make sure that their ­challenge would go to the final day next Sunday.

Arsenal got the job done, relief ­fusing with the euphoria when it was all over. The downpour at the very end was almost biblical, the ­hailstones pelting down too, the notorious Old Trafford roof getting a thorough examination and it ­certainly made for a vivid backdrop when Arteta and his players celebrated in front of the travelling fans.

Arsenal were well below their best in creative terms; their star players were defenders, namely Ben White and William Saliba. The result was the only thing that mattered. Does ­anyone think that City will slip up; they play their game in hand at ­Tottenham, of all places, on Tuesday night? City have never done so under Pep Guardiola when the title has been within their grasp. For Arsenal, it remains about believing.

Any pre-match optimism had been difficult to locate in United hearts and yet there was a ­tremendous roar from the home crowd upon the first ­whistle; excellent support ­throughout. It was surely in spite of the evidence contained on the team sheets. Call it blind faith, defiance. Or just backing your club.

Arsenal had been unchanged, ­bristling with assurance, ­momentum behind them. What remained so ­disorientating about United was the sheer number of absentees, ­especially at the back, where Casemiro ­continued alongside Jonny Evans in the wake of the horror show at Crystal Palace last Monday. There was no one else.

Arsenal were odds-on with some bookmakers to score at least three. Digest that, for a moment. Yet United appeared determined to show some personality and they might have scored first when Scott ­McTominay won the ball high up off Thomas Partey and, suddenly, ­Rasmus Højlund had a clear ­shooting chance. He slipped at the crucial moment.

United were good for the opening 20 minutes, winning a few duels, although Arsenal threatened on ­corners, Aaron Wan-Bissaka ­having to make one important clearing header. The problem, of course, is United’s near constant vulnerability, the sense that a structural breakdown is never far away.

It came when André Onana went long, Casemiro having shown for the short ball and White took a header from Saliba to feed it back up the inside right for Kai Havertz. The Arsenal centre-forward looked ­offside. That was until we looked along what passed for United’s line and saw Casemiro was still 10 yards back. Havertz ran around Evans to cross low. Trossard lost Wan-Bissaka to touch home.

Arsenal might have scored again on 29 minutes when White worked a give-and-go with the ­disappointing Bukayo Saka, burst away from Casemiro and lifted just off target. United, though, held their own up to the interval, despite struggling for clear-cut openings.

Ten Hag had recalled Sofyan ­Amrabat in midfield and he brought some muscle, earning a generous ovation when he was substituted late on. Amad Diallo, who started ahead of Antony on the right wing, showed twinkle toes and sharp turns. Kobbie Mainoo looked as if he could make something happen.

Arteta had won here previously as a manager, Arsenal’s lone league ­success of the recent past coming under him in November 2020 – the 1-0 pandemic ghost game that was ­settled by Pierre-Emerick ­Aubameyang’s penalty. Arteta needed his team to manage the game in the second-half. The longer it stayed at 1-0, the more his insides churned.

Declan Rice saw a shot blocked by Wan-Bissaka but with Diogo Dalot and Alejandro Garnacho driving variously up the left, the home crowd sensed an equaliser.

Garnacho was stopped in his tracks by one excellent Saliba tackle. On another occasion, the United winger dropped his shoulder to open up a shooting chance, stepping inside only to get the curler all wrong. ­Garnacho’s final action was too often a frustration.

It was nervy for everyone ­connected to Arsenal. They sat deep at times, in the second-half, inviting United to make the game. Martin Ødegaard sent one shot too close to Onana but at the other end Antony – having come off the bench – pinched the ball ahead of Takehiro Tomiyasu before fluffing the shot.

Garnacho kept going, it kept on being nearly but not quite for him while Onana tipped over from the Arsenal substitute Gabriel Martinelli. The goalkeeper would also paw clear a Wan-Bissaka backwards flick and a drive from Rice.

A concerned Novak Djokovic says he will undergo extra medical tests in relation to being struck by a water bottle after crashing out in the third round of the Italian Open.

The Serb had been signing autographs on Friday after his second-round win over Corentin Moutet when a metal bottle fell out of a fan’s backpack and directly on his head. After the initial blood and nausea, Djokovic said he had felt fine on Saturday as he returned to training, even entering the practice court jokingly wearing a helmet. On Sunday, though, he felt like a “different player” as he was defeated 6-2, 6-3 by Chile’s Alejandro Tabilo, the 29th seed.

“It was unexpected obviously,” said Djokovic. “I wasn’t even looking up. Then I felt a very strong hit in the head. That has really impacted me a lot. After that I got the medical care. Been through half an hour, an hour of nausea, dizziness, blood, a lot of different things. I managed to sleep OK. I had headaches.

“The next day or yesterday was pretty fine, so I thought it’s OK. Maybe it is OK. Maybe it’s not. I mean, the way I felt on the court today was just completely like a different player entered into my shoes. Just no rhythm, no tempo, no balance whatsoever on any shot. It’s a bit concerning.”

Tabilo arrived in Rome full of confidence after winning an ATP Challenger event in Aix-en Provence, rising to a career-high ranking of No 32. Still, Sunday marked by far the biggest win of his life. Despite his own issues, Djokovic was complimentary about the 26-year-old’s game. “I was trying not to think about it, trying to keep it point by point. And no, I can’t believe it, it’s crazy,” said Tabilo.

An athletic left-hander with a sweet serve and forehand, Tabilo stepped up to the world No 1 determined to take the first strike with his forehand, to control as many exchanges as possible and keep Djokovic on the move. It soon became clear that there was minimal resistance across the net. Djokovic gave away his opening service game with two double faults, including one on break point, and as Tabilo became increasingly comfortable on the front foot, the Serb struggled badly.

Alongside his passive play and unforced errors, Djokovic was extremely flat emotionally and he rushed between points, seemingly determined to get off the court as quickly as possible and his tournament ended with a miserable double fault off a 115mph second serve. Afterwards, Djokovic said that he did not undertake any medical checkups on his day off but, with two weeks until Roland Garros, he will now.

“I have to check that,” said Djokovic. “Training was different. I was going for kind of easy training yesterday. I didn’t feel anything, but I also didn’t feel the same. Today under high stress, it was quite bad – not in terms of pain, but in terms of this balance. Just no coordination. Completely different player from what it was two nights ago. Could be. I don’t know. I have to do medical checkups and see what’s going on.”

Djokovic produced one of the best seasons of his career in 2023, winning the Australian Open, French Open, US Open and ATP Finals, but this has been a curious year so far. The defeat means that Djokovic, who turns 37 this month, will head to the French Open yet to win a title in the season for the first time since 2018 and just the second time since he won his first title in 2006.

Meanwhile, Aryna Sabalenka continued to rebuild her momentum as she reached the fourth round with a 6-4, 6-2 win over Dayana Yastremska. It is the Australian Open champion’s first victory over the Ukrainian.

“I’m a better player right now,” said Sabalenka. “I got more stuff in my pocket to get this win against her. Yeah, our last matches were a long time ago when I was kind of on and off.

“I was just trying to find my way. I was going quite confident into this match knowing that I have everything to get the win. I’m super-happy to finally get the win against her.”

Donald Trump on Saturday praised fictional serial killer Hannibal Lecter “as a wonderful man” before segueing into comments disparaging people who have immigrated into the US without permission.

The former president’s remarks to political rally-goers in Wildwood, New Jersey, as he challenges Joe Biden’s re-election in November were a not-so-subtle rhetorical bridge exalting Anthony Hopkins’ cannibalistic Lecter in Silence of the Lambs as “late [and] great” while simultaneously condemning “people who are being released into our country that we don’t want”.

Trump delivered his address to an estimated crowd of about 80,000 supporters under the shadow of the Great White roller coaster in a 1950s-kitsch seaside resort 90 miles (144.8km) south of Philadelphia.

The occasion served for Trump to renew his stated admiration for Lecter, as he’s done before, after the actor Mads Mikkleson – who previously portrayed Lecter in a television series – once described Trump as “a fresh wind for some people”.

Among other comments, Trump on Sunday also reaired lies about having “been indicted more than the great Alphonse Capone”, the violent Prohibition-era Chicago mob boss.

Trump since the spring of 2023 has grappled with four indictments attributing more than 80 criminal charges to him for attempts to subvert the outcome of the 2020 election he lost to Biden, retaining classified materials after his presidency and hush-money payments to an adult film actor which prosecutors maintain were illicitly covered up.

The trial over the hush money is set to enter its fourth week Monday.

Yet Capone was indicted at least six times before his famous 1931 tax evasion conviction.

Trump nonetheless used the occasion to call the charges against him “bullshit”, with spectators then chanting the word back at him.

The Philadelphia Inquirer noted that the former president’s supporters had poured into Wildwood in “pickup trucks decked out in Trump flags” from up and down the east coast.

According to the outlet, hundreds of people set up camp overnight on the boardwalk to get into the event.

“The country is headed in the wrong direction,” Kelly Carter-Currier, a 62-year-old retired teacher from New Hampshire, told the Inquirer. “So, hopefully, people will get their shit together and vote the right person in. And if they don’t, I don’t know. World War III?”

On the other hand, New Jersey Democrats dismissed the significance of the event.

Congresswoman Mikie Sherrill said many of the Trump supporters expected would be from out of state. “Jersey is not going to be a welcoming place for Trump,” Sherrill said.

Sherrill’s fellow New Jersey Democrat Andy Kim, a congressman running for the US Senate, said that generalized apathy toward government helped Trump’s support.

“I hope people recognize that he is not somebody that has an agenda that’s going to lead to a better type of politics,” Kim said.

A British man settled in Italy who has a rare cancer has been unable to receive the free healthcare he is entitled to because local officials do not understand the Brexit withdrawal agreement, he has said.

Graham Beresford, 61, has spoken out days before the foreign secretary, David Cameron, who triggered the Brexit referendum, has his first major meeting with the European commission vice-president Maroš Šefčovič in Brussels about post-Brexit relations.

Under the withdrawal agreement, Beresford should be entitled to the same access to healthcare as an Italian pensioner, but he has repeatedly been told this is not correct and has faced demands of €2,000 (£1,700) for an Italian health card.

Campaigners say Beresford is one of hundreds of Britons in this situation.

“Brexit is the cause of this. Brexit is an absolute disaster, an act of self-harm of the worst kind for absolutely nothing. I don’t know why anyone voted for it,” said Beresford, who cannot, despite trying for years, persuade the local authorities he is entitled to healthcare under the Brexit deal.

Beresford managed energy for the local council in Glasgow, but took early retirement and moved to Italy in January 2019 to realise his retirement dream before the Brexit drawbridge in January 2021 which put a stop to free movement.

Initially he relied on savings, but when he reached 60 he was able to access his pension of about €10,000 (£8,600) a year.

Local authorities have told him that the withdrawal agreement gives health rights only to British nationals who were in the country for a full five years before the end of the transition period on 31 December 2020.

Attempts to convince authorities that they are making an error have been futile.

Cameron’s meetings with Šefčovič on Thursday – as part of the EU-UK joint committee and the EU-UK Partnership Council – are his first official stocktake of Brexit, and come eight years after he resigned over the referendum result.

One will focus on the trade and co-operation agreement, where energy co-operation, the fisheries deal and post-pandemic health security will be discussed, and the other on the withdrawal agreement in which citizens’ rights and an update on the Northern Ireland Windsor framework are on the agenda.

In February, the campaign group Brexpats – Hear Our Voice managed to get the Italian health ministry to circulate a two-page letter to local authorities confirming that Britons who were in Italy before Brexit were entitled to register for free with the Sistema Sanitorio Nazionale, the Italian version of the NHS.

This is also referenced on the UK government’s Living in Italy page.

When Beresford took a copy of the minister’s letter to the local authority, he was still met with resistance. “She told me ‘we need further clarification’,” he said, and they refused to issue him with his health card.

“Cameron needs to provide funding for the embassy to employ someone to help British citizens with Brexit issues,” said Beresford. “Brexit was not all enacted at once by the UK, it has been implemented transitionally, so it only stands to reason that citizens will be affected transitionally as each new act is implemented.”

Campaigners in Italy wrote to Cameron about the issue in January but have not received a reply.

Beresford, who is on chemotherapy drugs, said: “I just want to be able to have healthcare without having to worry week to week whether we are going to get a prescription or not.”

Clarissa Killwick from Brexpats – Hear Our Voice said Beresford’s case “highlights how extremely vulnerable some people are”, particularly because of the lack of “joined-up communications” which she said was a clear breach of article 37 of the withdrawal agreement.

She added: “The funding from the UK government for dedicated assistance for people such as Graham stopped in 2021 and, unlike in the UK, there is no independent monitoring of withdrawal agreement implementation. It is easy for 1.3 million people to become invisible when they are scattered across 27-plus countries.

“To have a hope of things functioning as they should, information needs to be timely, unambiguous and easily accessible.”

A spokesperson for the Foreign Office said: “Access to healthcare for British nationals living abroad under the UK-EU withdrawal agreement is a top priority for the UK.

“We are pressing the Italian authorities for clarity for those who are facing problems accessing healthcare services or where there is confusion around eligibility, and supporting affected individuals.”